lipid A

Screening of anti-endotoxin traditional Chinese medicine by target of Lipid A

以LipidA为靶点拮抗内毒素中药的筛选

Cloning expression and identification of single chain antibody against lipid A of bacterial endotoxin

抗内毒素类脂A单链抗体基因的克隆、表达和初步鉴定

Lipid A plays an important role in the pathogenesis of Gram-negative bacterial infections .

类脂A在革兰氏阴性菌的致病性方面起重要作用。

Effects of lipid A and LPS on mitochondrial dehydrogenase of human glomerular endothelial cells

类脂A和内毒素对人肾小球内皮细胞线粒体脱氢酶活性的影响

Study on monoclonal and antibody of genetic engineering single chain against lipid A of bacterio-endotoxin

抗内毒素类脂A单克隆和基因工程单链抗体的研究

The results of this study suggest that synthetic modified lipid A compounds may provide a new therapeutic tool against plague infection .

这项研究结果表明，合成改良后的脂质A复合物可为鼠疫感染提供一种新的治疗手段。

Screening of phage-display peptide library for mimicry peptide of lipid A

从噬菌体随机十五肽库中筛选类脂A模拟肽的研究

The cells grew larger with time , with irregular shape and droplets of lipid a - round the nucleus .

毛囊隆突细胞诱导培养7d后，细胞体积变大，随着时间延长，细胞进一步变大，细胞质中有脂滴样颗粒围绕在核的周围，细胞形状不规则。

Preparation and appraisement of the lipid A of Enterobacteriaceae and anti-lipid A antibodies

大肠杆菌类脂A及抗类脂A抗体的制备及鉴定

The LPS molecule can be divided into three parts : lipid A , core polysaccharides and O-antigen repeats .

LPS由类脂A、核心多糖和O-特异性多糖三部分组成。

The role of COX-2 expression in the delayed phase of monophosphoryl lipid A preconditioning in myocardial ischemia-reperfusion in rats

环氧化酶-2表达在单磷酰脂A诱导的大鼠延迟性心肌保护中的作用

An Experimental Study on Protective Effects of Monophosphoryl Lipid a Preconditioning with Cold Crystalloid Cardioplegia to Immature Myocardium

单磷酰脂A预处理结合冷晶体心肌保护液对未成熟心肌保护的实验研究

LPS is the heteropolymer consisting of two parts : the hydrophobic lipid A and hydrophilic polysaccharide .

脂多糖是包含疏水脂质和亲水多糖两部分的异聚物。

Tight stacking of the long-chain fatty acids of lipid A , the hydrophobic anchor of LPS , forms a permeability barrier around the cell .

类脂A中长脂肪链的紧密叠加以及LPS的疏水部共同形成了细菌的通透性屏障。

Whereas those endotoxin preparation lacking the terminal-portions ( Rc , Rd , Re and lipid A ) did not induce gut origin infection .

而缺乏多糖链终末片断的内毒素Rc，Rd和Re及类脂A均末能造成肠源性感染。

Delivery of a lipid A analogue that cannot incite a strong immune response might reduce or eliminate shock by acting as a decoy to keep immune system cells away from the real lipid A in the body .

把不会引起强烈免疫反应的脂质A类化合物，当成诱敌物注入体内，让体内免疫系统的细胞接触不到真正的脂质A，就可能降低或消除休克。

The biosynthetic pathway of lipid A in bacteria is relatively conservative , but structure modifications can occur during its transport to the bacterial surface . These modifications differ in bacteria in order to adapt to different external environment .

类脂A的合成途径相对保守，但在转运到外膜外侧的过程中它的结构会发生不同的修饰作用以适应不同的外界环境。

Conclusions PMB exerts its protection effect on septic mice by inhibiting macrophages , as may be related to the neutralization of LPS , in which the affinity of PMB with Lipid A plays an important role .

结论PMB可能通过抑制巨噬细胞活化实现对脓毒症小鼠的保护作用，其机制可能与PMB与LipidA结合后中和LPS的活性有关。

The mechanism of H on LPS degradation was fractionization of phosphoryl in position 1 from lipid A , while that of G was complex , it could bound LPS molecule and influenced its effect besides LPS hydrolysis .

实验证实30%双氧水能裂解LPS类脂A还原端C1位上的磷酸基团，而大蒜作用机理较复杂，除水解作用外，还能螯合LPS分子，影响LPS单体发挥作用。

By using a monoclonal antibody specific to the core lipid A region of lipopolysaccharides ( LPS ) and immunofluorescent technique , effects of serum on the uptake process of two types of LPS were observed with a confocal laser scanning microscope .

本文应用单克隆抗细菌脂多糖抗体，利用免疫荧光及激光共聚焦扫描技术，观察了分离培养的枯否细胞在有无血清条件下对二种不同分子结构细菌脂多糖摄取过程的影响。

Pharmacological preconditioning has become a research hotspot , previous researches show that many drugs ( such as adenosine , monophosphoryl lipid A , K-ATP channel opener , inhaled anesthetics and opioids ) can mimic ischemic preconditioning .

药物预处理已经成为心肌保护研究的热点，研究表明许多药物如腺苷、单磷酰酯A、K-ATP通道开放剂、吸入性麻醉药和阿片类麻醉药等均可以模拟缺血预处理产生心脏保护作用。

On the other hand , all of the four clones were able to inhibit the binding of Clone 20 to solid phase-bound lipid A ( in ELISA ) and Re - LPS ( in ELISA and passive hemolysis assay ) .

在被动溶血试验中，Clone20与固相Re－LPS的结合，也为4个克隆所抑制。

The main component of the endotoxin , lipopolysaccharide ( LPS ) derived from the outer membrane of Gram-negative bacteria cell wall is composed by the core oligosaccharide , specific polysaccharide and lipid A which is the active site and the center virulence of LPS .

脂多糖（LPS）是内毒素的主要成分，来源于革兰氏阴性菌细胞壁的外膜，由核心寡聚糖、特异性多糖与类脂A组成，其中类脂A是LPS的活性部位以及毒力中心。

Fat and lipid are a kind of natural cosmetic material with rich resources and wide uses .

油脂和类脂是一种资源比较丰富、用途较广泛的天然化妆品原料。

The LPS activating effect of HUVEC membrane lipid showed a typical property of enzymatic dynamics .

LPS激活膜磷脂代谢的反应特性表现出典型的酶促动力学特性。

Using traditional Chinese medicine to regulate blood lipid becomes a hot research field for its superior curative effects and few side effects .

中药调脂以其疗效好、副作用小的优势而成为研究的热点，从中医的整体观念出发，在多个环节上干预高脂血症的形成和治疗。

The auto-oxidizable reaction of lipid is a complex organic chemistry reaction which do latent harm to humankind .

脂质自动氧化反应是一个复杂的有机化学反应，同时给人带来潜在的危害。

PCC is composed of lipid , a peptide and carbohydrate in the ratio of 1.76:1.00: 0.27 . The total lipids was separated into six fractions .

脂：肽：糖比例为1.76：1.00：0.27。

It was also observed that , at the end of feeding trial , the whole body lipid has a tendency to decrease with the increment of dietary phosphorus levels , even though there is no significant difference among treatments ( p > 0.05 );

全鱼脂肪含量随饲料磷水平上升而呈下降趋势，但各试验组间无显著差异（p>0.05）。

Objective To review the new research development of the solid lipid nanoparticles as a drug delivery system .

目的综述固脂纳米粒作为药物释放系统的最新研究进展。